Cresp, T. M.; Sargent, M. V.; Elix, J. A.; Murphy, D. P. H. published an article in 1973, the title of the article was Formylation and bromination ortho to the hydroxy-group of 2-carbonyl-substituted phenols in the presence of titanium(IV) chloride.Name: Methyl 5-bromo-2-methoxy-4-methylbenzoate And the article contains the following content:
Formylation with Cl2CHOMe-TiCl4 of Me 2,4-dihydroxybenzoate, Me 2-hydroxy-4-methoxybenzoate, Et 2-hydroxy-4-methoxy-6-methylbenzoate, Me 2-hydroxy-4-methylbenzoate, and 2-hydroxy-4-methoxyacetophenone gave the 3-formyl derivatives as the major products. Bromination in the presence of TiCl4 gave similar results. Formation of a six-membered ring Ti complex (e.g., I) induces selective substitution ortho to the OH group. The experimental process involved the reaction of Methyl 5-bromo-2-methoxy-4-methylbenzoate(cas: 39503-58-7).Name: Methyl 5-bromo-2-methoxy-4-methylbenzoate
The Article related to selective formylation phenol derivative, formylation hydroxybenzoate titanium chloride, phenol carboxy formylation titanium, bromination hydroxybenzoate titanium chloride, chloromethyl ether formylation phenol derivative and other aspects.Name: Methyl 5-bromo-2-methoxy-4-methylbenzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary