On January 31, 2022, Gao, Yong; Fu, Zhenda; Wu, Di; Yin, Hongquan; Chen, Fu-Xue published an article.Formula: C13H11Br The title of the article was Organocatalyzed Asymmetric Tandem Intramolecular oxa-Michael Addition/Electrophilic Thiocyanation: Synthesis of Chiral α-Thiocyanato Flavanones. And the article contained the following:
An efficient bifunctional cinchona alkaloids-catalyzed asym. tandem intramol. oxa-Michael addition/electrophilic thiocyanation of alkylidene β-ketoesters with N-thiocyanatosuccinimide (NTS) was developed. A series of chiral α-thiocyanato flavanones containing two vicinal stereocenters including an all-carbon quaternary center I [R1 = H, 7-Me, 6-Cl; R2 = Ph, 2-naphthyl, 2-thienyl, etc.; R3 = Me, Et, t-Bu] were prepared in good yields with excellent diastereo- and enantioselectivities (up to 97% ee) under mild conditions, and a successful scale up preparation of our protocol was also demonstrated. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Formula: C13H11Br
The Article related to chiral thiocyanato flavanone preparation, alkylidene ketoester thiocyanatosuccinimide asym tandem michael addition thiocyanation organocatalyst, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Formula: C13H11Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary