In 2022,Abdellaoui, O.; Chraibi, M.; Skalli, M. K.; Haoudi, A.; Fikri-Benbrahim, K.; Rodi, Y. Kandri; Mazzah, A.; Senhaji, O. published an article in Asian Journal of Chemistry. The title of the article was 《Synthesis and antibacterial evaluation of three quaternary ammonium surfactants based on isatin》.Safety of 1,6-Dibromohexane The author mentioned the following in the article:
In present study, several isatin-derived quaternary ammonium surfactants I [n = 3, 6, 12] with different carbon chain lengths were designed and synthesized. They were synthesized by alkylation of indoline-2,3-dione with various dibromo-alkanes, then quaternization with trimethylamine. Further, the critical micelle concentrations (CMC) value of surfactants I synthesized was determined in an aqueous solution using elec. conductivity The synthesized surfactants I had CMC ranging from 0.01 to 0.012 mol/L. The antibacterial activity of the titer compounds I was evaluated against gram-neg. bacteria (P. aeruginosa and E. coli), as well as gram-pos. bacteria (S. aureus). The surfactant with a long hydrocarbon chain I [n = 12] showed activity against all bacteria tested (min. inhibitory concentration = 1.25-2.5 mg/mL), whereas those with a short hydrocarbon chain proved to be inactive. After reading the article, we found that the author used 1,6-Dibromohexane(cas: 629-03-8Safety of 1,6-Dibromohexane)
1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Safety of 1,6-Dibromohexane
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary