Bian, Kang-Jie; Li, Yan; Zhang, Kai-Fan; He, Yan; Wu, Tian-Rui; Wang, Cheng-Yu; Wang, Xi-Sheng published an article in 2020, the title of the article was Iron-catalyzed remote functionalization of inert C(sp3)-H bonds of alkenes via 1,n-hydrogen-atom-transfer by C-centered radical relay.Product Details of 574-98-1 And the article contains the following content:
Enabled by 1,n (n = 5, 6)-hydrogen atom transfer (HAT), a most prevalent moiety, alkene, as the precursor to an sp3 C-centered radical to promote selective cleavage of inert C(sp3)-H bonds for the generation of azidotrifluoromethylated mols. I [R1 = Me, n-Bu, Ph, etc.; R2 = H, Me, Et, n-octyl; R1R2 = (CH2)3, (CH2)4, (CH2)2O(CH2)2, etc.; X = C(CO2Et)2, C(CH2OBz)2, NTs] was used. Mild conditions, broad scope and excellent regioselective control (>20 : 1) were observed in the reactions. Deuterium labeling studies disclosed the kinetic characteristics of the transformations and verify a direct 1,n-HAT pathway. The key to this C-centered radical relay was that iron played a dual role as a radical initiator and terminator to incorporate the azide functionality through radical oxidation via azido-ligand-transfer. The methods and the later derivatization promised expeditious synthesis of CF3-containing organic azides, γ-lactam and triazoles that were widely used in designing new fluorescent tags and functional materials. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Product Details of 574-98-1
The Article related to azidotrifluoromethylated mol preparation regioselective, alkene trimethylsilyl azide azidotrifluoromethylation iron catalyzed, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 574-98-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary