On February 8, 2022, Li, Yingying; Jiang, Zhimin; Duan, Xiaoqun; Wei, Riming; Chen, Yijie; Fan, Xinxin; Liu, Jieyu; Su, Huilin published a patent.Formula: C24H27Br2P The title of the patent was Artesunate derivatives as antitumor agents and their preparation, pharmaceutical compositions and use in the treatment of cancer. And the patent contained the following:
The invention relates to the tech. field of medicine, and specifically discloses artesunate derivatives I•Br- and II•Br- (n is 6-20; R1 is C1-6 alkyl) and preparation method and application thereof. Compounds I and II were prepared by using alkylation and esterification as the key steps. All the invention compounds were evaluated for their antitumor activity. The artesunate derivatives provided by the present invention have novel skeleton structure and excellent antitumor activity, and can be used for the preparation of antitumor drugs. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Formula: C24H27Br2P
The Article related to artesunate derivative preparation antitumor treatment cancer, Terpenes and Terpenoids: Sesquiterpenes (C15), Including Ionones and other aspects.Formula: C24H27Br2P
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary