On April 30, 2022, Liang, Xiao; Li, Xue; Zhao, Zhiyuan; Nie, Yiming; Yao, Zefu; Ren, Wandi; Yang, Xinying; Hou, Xuben; Fang, Hao published an article.Category: bromides-buliding-blocks The title of the article was Design, synthesis and biological evaluation of hydantoin derivatives as Mcl-1 selective inhibitors. And the article contained the following:
Herein, authors designed and synthesized a series of hydantoin derivatives I (R1 = H, Ph, OCH2Ph, etc.; R2 = Me, Bn, CH2-Ph-Ph, etc.; R3 = H, 3-NO2-4-Cl) as novel myeloid cell leukemia-1 (Mcl-1) inhibitors based on authors’ previously developed lead compound Among them, compound I (R1 = -OCH2-3,4-di-Cl-Ph; R2 = -CH2-Ph-OCH2-4-Cl-Ph; R3 = 3-NO2-4-Cl) and I (R1 = O(CH2)2-O-3,5-diMe-4-Cl-Ph; R2 = -CH2-Ph-OCH2-4-Cl-Ph; R3 = 3-NO2-4-Cl) exhibited good binding affinities against Mcl-1 with Ki values of 0.49μM and 0.33μM resp. Especially, compound I (R1 = -OCH2-3,4-di-Cl-Ph; R2 = -CH2-Ph-OCH2-4-Cl-Ph; R3 = 3-NO2-4-Cl) exhibited good selectivity over Bcl-xL, whereas compound I (R1 = O(CH2)2-O-3,5-diMe-4-Cl-Ph; R2 = -CH2-Ph-OCH2-4-Cl-Ph; R3 = 3-NO2-4-Cl) possessed good selectivity over both Bcl-2 and Bcl-xL. Furthermore, authors also investigated the effects of these new Mcl-1 inhibitors on cell proliferation, apoptosis and mitochondrial membrane potential, as well as the stability in plasma. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Category: bromides-buliding-blocks
The Article related to hydantoin preparation antitumor human mcl1 inhibitor apoptosis, apoptosis, cancer, hydantoin derivatives, mcl-1 inhibitors, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary