Liu, Sien; He, Bangyue; Li, Hongyi; Zhang, Xiaofeng; Shang, Yaping; Su, Weiping published their research in Chemistry – A European Journal in 2021. The article was titled 《Facile Synthesis of Alkylidene Phthalides by Rhodium-Catalyzed Domino C-H Acylation/Annulation of Benzamides with Aliphatic Carboxylic Acids》.Related Products of 76006-33-2 The article contains the following contents:
Facile synthesis of alkylidene phthalides I [R1 = H, Me, Ph, etc.; R2 = H, 3-Me, 3-Ph, etc.; R3 = H, Me, Et, etc.; R4 = Et, i-Pr, n-Bu, etc; R3R4 = CH2(CH2)2CH2, CH2(CH2)4CH2] by rhodium-catalyzed domino C-H acylation/annulation of benzamides with aliphatic carboxylic acids. The Rh-catalyzed ortho-C(sp2)-H functionalization of 8-aminoquinoline-derived benzamides with aliphatic acyl fluorides generated in situ from the corresponding acids was developed. This reaction initiated with 8-aminoquinoline-directed ortho-C(sp2)-H acylation, which was accompanied by subsequent intramol. nucleophilic acyl substitution of amide group to produce alkylidene phthalides. This approach exhibited high stereo-selectivity for Z-isomer products and tolerates a variety of functional groups as well as aliphatic carboxylic acids with diverse structural scaffolds. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Related Products of 76006-33-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary