Min, Rui; Wu, Weibin; Wang, Mingzhong; Tang, Lin; Chen, Dawei; Zhao, Huan; Zhang, Cunlong; Jiang, Yuyang published an article in 2019, the title of the article was Discovery of 2-(1-(3-(4-chloroxyphenyl)-3-oxo- propyl)pyrrolidine-3-yl)-1H-benzo[d]imidazole-4-carboxamide: a potent poly(ADP-ribose) polymerase (PARP) inhibitor for treatment of cancer.SDS of cas: 574-98-1 And the article contains the following content:
A series of benzimidazole carboxamide derivatives have been synthesized and characterized by 1H-NMR, 13C-NMR and HRMS. PARP inhibition assays and cellular proliferation assays have also been carried out. Compounds 5cj and 5cp exhibited potential anticancer activities with IC50 values of about 4 nM against both PARP-1 and PARP-2, similar to the reference drug veliparib. The two compounds also displayed slightly better in vitro cytotoxicities against MDA-MB-436 and CAPAN-1 cell lines than veliparib and olaparib, with values of 17.4 microM and 11.4 microM, 19.8 microM and 15.5 microM, resp. The structure-activity relationship based on mol. docking was discussed as well. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).SDS of cas: 574-98-1
The Article related to breast cancer parp inhibitor, parp enzyme inhibition, benzimidazole carboxamide, poly(adp-ribose) polymerase, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.SDS of cas: 574-98-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary