On August 5, 2004, Poupart, Marc-Andre; Beaulieu, Pierre Louis; Rancourt, Jean published a patent.Application In Synthesis of Methyl 5-bromo-2-methoxy-4-methylbenzoate The title of the patent was A preparation of heterocyclic compounds, useful as inhibitors of RNA dependent RNA polymerases, such as hepatitis C virus polymerase. And the patent contained the following:
The invention relates to a preparation of heterocyclic compounds of formula I [wherein: R1 is (cyclo)alkyl, cycloalkenyl, 4 to 7-membered heterocyclic ring, etc.; R2 is halogen or (un)substituted (hetero)aryl; B is N and A is :CH-, or :N-, etc.; B is :C- and A is O, S, or NH, etc.; M1 and M4 are independently selected from CR3; M2 and M3, when not linked to -C(:Y)Z, is CR3; R3 is H, halogen, CN, or azido, etc.], useful as inhibitors of RNA dependent RNA polymerases, particularly those viral polymerases within Flaviviridae family, more particularly to hepatitis C virus (HCV) polymerase. For instance, NS5B RNA dependent RNA polymerase inhibition of pyridinylindole derivative II was determined (compound 101, table 1; IC50 < 1μM). The experimental process involved the reaction of Methyl 5-bromo-2-methoxy-4-methylbenzoate(cas: 39503-58-7).Application In Synthesis of Methyl 5-bromo-2-methoxy-4-methylbenzoate
The Article related to heterocycle preparation hepatitis c virus hcv rna polymerase inhibitor, flaviviridae hepatitis c virus polymerase inhibitor heterocycle preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application In Synthesis of Methyl 5-bromo-2-methoxy-4-methylbenzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary