On May 5, 2022, Sblano, Sabina; Cerchia, Carmen; Laghezza, Antonio; Piemontese, Luca; Brunetti, Leonardo; Leuci, Rosalba; Gilardi, Federica; Thomas, Aurelien; Genovese, Massimo; Santi, Alice; Tortorella, Paolo; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio published an article.Electric Literature of 2567-29-5 The title of the article was A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity. And the article contained the following:
The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in the regulation of the metabolic homeostasis and therefore represent valuable therapeutic targets for the treatment of metabolic diseases. The development of more balanced drugs interacting with PPARs, devoid of the side-effects showed by the currently marketed PPARĪ³ full agonists, is considered the major challenge for the pharmaceutical companies. Here we present a chemoinformatics search approach for new ligands that let us identify a novel PPAR pan-agonist with a very attractive activity profile being able to reduce lipid accumulation and improve insulin sensitivity. This compound represents, therefore, the potential lead of a new class of drugs for treatment of dyslipidemic type 2 diabetes. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5
The Article related to ppar pan agonist glucose uptake chemoinformatic docking, chemoinformatics search, docking experiments, glucose uptake, ppar pan-agonist, Placeholder for records without volume info and other aspects.Electric Literature of 2567-29-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary