Wang, Lin; Fang, Zhijie published an article in 2020, the title of the article was Study on the synthesis and biological activities of N-alkylated deoxynojirimycin derivatives with a terminal tertiary amine.Electric Literature of 574-98-1 And the article contains the following content:
A series of N-alkylated deoxynojirimycin (DNJ) derivatives I (n = 1, 3; R = R1 = Me; RR1 = -(CH2)4-, -(CH2)5-, -(CH2)2O(CH2)2-) connected to a terminal tertiary amine at the alkyl chains of various lengths was prepared These novel synthetic compounds I were assessed for preliminary glucosidase inhibition and anticancer activities in vitro. Potent and selective inhibition was observed among them. Compound I (n = 1; RR1 = -(CH2)2O(CH2)2-) II (IC50 = 0.052μM) showed improved and selective inhibitory activity against β-glucosidase compared to DNJ (IC50 = 0.65μM). In addition, anal. of the kinetics of enzyme inhibition by using Lineweaver-Burk plots indicated that II inhibited β-glucosidase in a competitive manner, suggesting that II was expected to bind to the active site of β-glucosidase. Compounds I [n = 3; RR1 = -(CH2)4-, -(CH2)5-] were found to be moderate and selective inhibitors of α-glucosidase. Nevertheless, none of compounds inhibited the growth of B16F10 melanoma cells. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Electric Literature of 574-98-1
The Article related to tertiary amine alkyl deoxynojirimycin preparation glucosidase inhibition antitumor activity, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Electric Literature of 574-98-1
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