On June 21, 2021, Zhang, Chun; Zhang, Chao; Tang, Jie; Ye, Shengqing; Ma, Mingliang; Wu, Jie published an article.HPLC of Formula: 2567-29-5 The title of the article was Synthesis of γ-Keto Sulfones through a Three-Component Reaction of Cyclopropanols, DABCO·(SO2)2 and Alkyl Halides. And the article contained the following:
A route to γ-keto sulfones RC(O)(CH2)2SO2R1 [R = 4-FC6H4, Bn, 2-naphthyl, etc.; R1 = Me, Bn, 4-BrC6H4CH2, etc.] through a metal-free reaction of cyclopropanols, DABCO·(SO2)2 and alkyl halides was described. This reaction occurs under mild conditions in the absence of any catalysts, additives, or oxidants. Various functional groups including as ester, amino, methoxy, bromo, trifluoromethyl, nitro and carbonyl were tolerated well in this transformation and the corresponding γ-keto sulfones were afforded in 35% to 95% yields. The proposed mechanism implies that this reaction proceeded through γ-keto sulfinate intermediate generated in situ, which further undergoes nucleophilic substitution with alkyl halides leading to γ-keto sulfones. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).HPLC of Formula: 2567-29-5
The Article related to gamma keto sulfone preparation, cyclopropanol alkyl halide dabco bissulfur dioxide three component, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 2567-29-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary