Zhang, Jie; Song, Xue; Chen, Zhi-Chao; Du, Wei; Chen, Ying-Chun published an article in 2022, the title of the article was Phosphine-catalysed intermolecular cyclopropanation reaction between benzyl bromides and activated alkenes.Reference of 4-(Bromomethyl)-1,1′-biphenyl And the article contains the following content:
While phosphine-mediated reactions were extensively explored over the past few decades, the catalytic cyclopropanation reaction via a phosphonium ylide pathway has been significantly underdeveloped, and an intermol. version still remains to be disclosed. Presented herein was a catalytic cyclopropanation reaction between readily available benzyl bromides and activated alkenes, such as α-cyano chalcones, through in situ formation of phosphonium ylide intermediates. A spectrum of densely functionalized cyclopropane derivatives was efficiently constructed with excellent diastereoselectivity, which can be further converted to five-membered heterocycles after simple transformations. Moreover, moderate enantioselectivity can be obtained by using a com. available DuPhos catalyst. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Reference of 4-(Bromomethyl)-1,1′-biphenyl
The Article related to aralkyl bromide carbonyl cyanochalcone phosphine catalyst diastereoselective cyclopropanation, carbonyl cyanocyclopropane preparation, General Organic Chemistry: Synthetic Methods and other aspects.Reference of 4-(Bromomethyl)-1,1′-biphenyl
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary