On May 29, 2018, Zhu, Bin published a patent.Name: 2-Bromo-4-(bromomethyl)-1-methylbenzene The title of the patent was Microglial cell IL-1β secretion inhibitor, and its preparation method and application in treatment of neuroinflammatory diseases. And the patent contained the following:
The title microglial cell IL-1β secretion inhibitor is (((2,5-dibromocyclopenta-2,4-diene-1,1-diyl)bis(methylene))bis(6-alkyl-3,1-phenylene))diboronic acid, has structural formula shown as formula I in Claim 1, wherein R is C1-C10 alkyl or C3-C8 cycloalkyl. The invention also provides preparation method of above compound from cyclopenta-1,3-diene, 2-bromo-4-(bromomethyl)-1-alkylbenzene, boric acid, and bromine. The invention also provides application of the microglial cell IL-1β secretion inhibitor in preparation of drugs for treatment of neuroinflammatory diseases. The experimental process involved the reaction of 2-Bromo-4-(bromomethyl)-1-methylbenzene(cas: 259231-26-0).Name: 2-Bromo-4-(bromomethyl)-1-methylbenzene
The Article related to bromocyclopenta dienediyl diboronic acid preparation neuroinflammatory disease treatment, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Name: 2-Bromo-4-(bromomethyl)-1-methylbenzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary