Battistuzzi, Gianfranco; Cacchi, Sandro; Fabrizi, Giancarlo; Bernini, Roberta published an article in Synlett. The title of the article was 《3-Arylpropanoate esters through the palladium-catalyzed reaction of aryl halides with acrolein diethyl acetal》.Category: bromides-buliding-blocks The author mentioned the following in the article:
The reaction of aryl halides with acrolein di-Et acetal in the presence of Pd(OAc)2, n-Bu3N, and n-Bu4NCl in DMF at 90° affords Et 3-arylpropanoates. A variety of functional groups are tolerated in the aryl halides, including ether, aldehyde, ketone, ester, nitrile, and nitro groups. Ortho-substituents do not hamper the reaction. 3-Arylpropanoate esters were isolated in good to excellent yields with many neutral, electron-rich and electron-poor aryl iodides and electron-poor aryl bromide. Neutral and electron-rich aryl bromides gave the desired ester in moderate yields. After reading the article, we found that the author used Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1Category: bromides-buliding-blocks)
Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary