Formula: C4H6BrFO2On October 3, 2019 ,《Copper-catalyzed remote C-H monofluoromethylation of 8-aminoquinolines with dimethyl phosphonate as reductant》 was published in Tetrahedron Letters. The article was written by Han, Shuaijun; Wu, Qingsong; Mele, Lucas; Ding, Licheng; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie. The article contains the following contents:
A simple and efficient copper-catalyzed monofluoromethylation of 8-aminoquinolines with 2-bromo-2-fluoroacetate was described with HPO(OMe)2 (di-Me phosphonate) as reductant. The reaction tolerated a variety of quinoline amides and monofluoroalkyl bromides. Significant advantages of this protocol include synthetic convenience and high reaction efficiency. The experimental process involved the reaction of Ethylbromofluoroacetate(cas: 401-55-8Formula: C4H6BrFO2)
Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Formula: C4H6BrFO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary