Huang, Hong-Gui; Li, Weishuang; Zhong, Dayou; Wang, Hu-Chong; Zhao, Jing; Liu, Wen-Bo published their research in Chemical Science in 2021. The article was titled 《Trifluoromethanesulfonyl azide as a bifunctional reagent for metal-free azidotrifluoromethylation of unactivated alkenes》.Computed Properties of C4H7BrO2 The article contains the following contents:
A simple and metal-free method that rapidly provides these building blocks, e.g., I from abundant alkenes RR1C=CR2R3 (R = 3-[(pyridin-3-yl)carbonyloxy]propyl, C8H17, CH2C6H5, etc.; R1 = H, Me, n-Pr; R2 = R3 = H, Me) and trifluoromethanesulfonyl azide (N3SO2CF3). This unprecedented two-component reaction employs readily available N3SO2CF3 as a bifunctional reagent to concurrently incorporate both CF3 and N3 groups, which avoids the use of their expensive and low atom economic precursors. A wide range of functional groups, including bio-relevant heterocycles and amino acids, was tolerated. Application of this method was further demonstrated by scale-up synthesis (5 mmol), product derivatization to CF3-containing medicinal chem. motifs, as well as late-stage modification of natural products, e.g., 5-(2,2,2-trifluoroethyl)pyrrolidin-2-one and drug derivatives In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Computed Properties of C4H7BrO2) was used in this study.
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Computed Properties of C4H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary