The author of 《Halting hyaluronidase activity with hyaluronan-based nanohydrogels: development of versatile injectable formulations》 were Montanari, E.; Zoratto, N.; Mosca, L.; Cervoni, L.; Lallana, E.; Angelini, R.; Matassa, R.; Coviello, T.; Di Meo, C.; Matricardi, P.. And the article was published in Carbohydrate Polymers in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:
Hyaluronan (HA) is among the most used biopolymers for viscosupplementation and dermocosmetics. However, the current injectable HA-based formulations present relevant limitations: (I) unmodified HA is quickly degraded by endogenous hyaluronidases (HAase), resulting in short lasting properties; (II) crosslinked HA, although shows enhanced stability against HAase, often contains toxic chem. crosslinkers. As such, herein, we present biocompatible self-assembled hyaluronan-cholesterol nanohydrogels (HA-CH NHs) able to bind to HAase and inhibit the enzyme activity in vitro, more efficiently than currently marketed HA-based crosslinked formulations (e.g. Jonexa). HA-CH NHs inhibit HAase through a mixed mechanism, by which NHs bind to HAase with an affinity constant 7-fold higher than that of native HA. Similar NHs, based on gellan-CH, evidenced no binding to HAase, neither inhibition of the enzyme activity, suggesting this effect might be due to the specific binding of HA-CH to the active site of the enzyme. Therefore, HA-CH NHs were engineered into injectable hybrid HA mixtures or phys. hydrogels, able to halt the enzymic degradation of HA. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Category: bromides-buliding-blocks) was used in this study.
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary