In 2019,Catalysts included an article by Willot, Sebastien J.-P.; Tieves, Florian; Girhard, Marco; Urlacher, Vlada B.; Hollmann, Frank; de Gonzalo, Gonzalo. Quality Control of Ethyl 5-bromovalerate. The article was titled 《P450BM3-catalyzed oxidations employing dual functional small molecules》. The information in the text is summarized as follows:
A set of dual functional small mols. (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P 450 monooxygenase P450BM3 from Bacillus megaterium in H2O2-dependent oxidation reactions. These DFSMs enhance P450BM3 activity with hydrogen peroxide as an oxidant, converting these enzymes into formal peroxygenases. This system has been employed for the catalytic epoxidation of styrene and in the sulfoxidation of thioanisole. Various P450BM3 variants have been evaluated in terms of activity and selectivity of the peroxygenase reactions. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Quality Control of Ethyl 5-bromovalerate)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Quality Control of Ethyl 5-bromovalerate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary