《Ferrocene functionalized upconversion nanoparticle nanosystem with efficient near-infrared-light-promoted fenton-like reaction for tumor growth suppression》 was written by Zhou, Jimin; Zhu, Xiangfeng; Cheng, Qianya; Wang, Yuxuan; Wang, Ruiqi; Cheng, Xingwen; Xu, Jiajia; Liu, Kuntang; Li, Lin; Li, Xueming; He, Mingfang; Wang, Jian; Xu, Heng; Jing, Su; Huang, Ling. Synthetic Route of C4H7BrO2 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:
By taking advantage of the efficient Forster resonance energy transfer (FRET) between near-IR (NIR)-responsive lanthanide-doped upconversion nanoparticles (UCNPs) and Fenton reagent ferrocenyl compounds (Fc), a series of Fc-UCNPs was designed by functionalizing NaYF4:Yb,Tm nanoparticles with Fc1-Fc5via surface-coordination chem. Fc-UCNP-Lipo nanosystems were then constructed by encapsulating Fc-UCNP inside liposomes for efficient delivery. Fc-UCNP can effectively release ·OH via a NIR-promoted Fenton-like reaction. In vitro and in vivo studies of Fc1-UCNP-Lipo confirmed the preferential accumulation in a tumor site followed by an enhanced uptake of cancer cells. After cellular internalization, the released Fc1-UCNP can effectively promote ·OH generation for tumor growth suppression. Such a Fc1-UCNP-Lipo nanosystem exhibits advantages such as easy fabrication, low drug dosage, and no ferrous ion release. By integrating the advantages of NIR-responsive lanthanide-doped UCNPs, a ferrocenyl compound Fc that catalyzes intracellular H2O2 for ·OH generation in tumor sites, as well as good delivery capability of liposomes, Fc-UCNP-Lipo nanosystem was constructed to realize significant tumor growth suppression via a NIR-promoted Fenton-like reaction. A good overlap of absorption spectra of Fc and emission spectra of UCNP is essential for efficient FRET. This nanosystem exhibits merits of low dosage and sustained and on-demand cancer therapy. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobutanoic acid(cas: 2623-87-2Synthetic Route of C4H7BrO2)
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Synthetic Route of C4H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary