Hu, Qi-Long; Liu, Jia-Tian; Li, Jian; Ge, Yang; Song, Zhendong; Chan, Albert S. C.; Xiong, Xiao-Feng published an article in 2021. The article was titled 《Demethylative alkylation of methionine residue by employing the sulfonium as the key intermediate》, and you may find the article in Organic Letters.Computed Properties of C9H9BrO2 The information in the text is summarized as follows:
Methionine (Met) offers a valuable handle to achieve peptide chem. modification owing to its unique thioether functional group. In contrast with cysteine, the site-selective functionalization of the hydrophobic and redox-sensitive thioether motif on peptides is still challenging, and strategies for diversification on the Met residue are rarely disclosed. Herein we report a transition-metal-free and redox-neutral approach for Met diversification with substrate diversity, which could be applied to synthesize cyclic peptides. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Computed Properties of C9H9BrO2)
Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Computed Properties of C9H9BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary