Synthetic Route of C4H6BrFO2On November 22, 2021 ,《Cobalt-Catalyzed Addition of Ethyl Bromofluoroacetate to Alkynes》 appeared in ChemistrySelect. The author of the article were Hu, Zhaoming; Ren, Jie; Chen, Zhizhi; Yin, Siyu; Wu, Fanhong; Liu, Chao; Wu, Zhuo; Wu, Jingjing. The article conveys some information:
A cobalt-catalyzed oxidative monofluoroalkylation of alkynes with Et bromofluoroacetate was reported. This method enabled direct and facile access to Et bromomonofluoroallyl acetate EtOC(O)CCHFR1C=CBrR2 [R1 = H, Me, n-Pr, n-Bu, Ph; R2 = n-Pr, Ph, 3-pyridyl, etc.] from abundant alkynes with excellent functional group compatibility. Moreover, this cobalt/ethyl bromofluoroacetate protocol could further create a series of radical monofluoroalkylation reactions of a wide array of substrates, offering a generic and complementary platform for the construction of diversified C-CFHCOOEt bonds. In the part of experimental materials, we found many familiar compounds, such as Ethylbromofluoroacetate(cas: 401-55-8Synthetic Route of C4H6BrFO2)
Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Synthetic Route of C4H6BrFO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary