Luan, Yu-Yong; Gou, Xue-Ya; Shi, Wei-Yu; Liu, Hong-Chao; Chen, Xi; Liang, Yong-Min published an article on February 11 ,2022. The article was titled 《Three-Component Ruthenium-Catalyzed meta-C-H Alkylation of Phenol Derivatives》, and you may find the article in Organic Letters.SDS of cas: 401-55-8 The information in the text is summarized as follows:
Herein, synthesis of phenyl-(pyrimidinyloxyphenyl)butanoates I [R1 = H, Me, Cl, etc.; R2 = H, Me, F, etc; R3 = Me, F; R4 = Ph, 4-FC6H4, 4-BrC6H4, etc.; R2 = R3 = Me, F; R5 = OEt, piperidin-1-yl, N(n-Bu)2] via three-component ruthenium catalyzed C-H alkylation of phenoxypyrimidines and vinylbenzene and ethyl-bromo-difluoroacetates/alkyl bromides was reported. This strategy exhibited good substrates suitability and functional group tolerance with various phenol derivatives, which provided a synthetic potential drug approach. Mechanistic studies showed that a radical process might be involved in this process. In addition, the meta alkylated phenol was obtained by further removal of the directing group. The experimental process involved the reaction of Ethylbromofluoroacetate(cas: 401-55-8SDS of cas: 401-55-8)
Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.SDS of cas: 401-55-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary