Zhou, Nengneng; Xia, Ziqin; Kuang, Kaimo; Xu, Qiankun; Zhao, Fangli; Wang, Lei; Zhang, Man published their research in Organic Letters on August 12 ,2022. The article was titled 《Visible-Light-Induced Difluoroalkylation of 1-(Allyloxy)-2-(1-arylvinyl)benzenes and 1-(1-Arylvinyl)-2-(vinyloxy)benzenes: Synthesis of Bis-Difluoroalkylated Benzoxepines and 2H-Chromenes》.Application In Synthesis of Ethylbromofluoroacetate The article contains the following contents:
A novel visible-light-mediated difluoroalkylation of 1-(allyloxy)-2-(1-arylvinyl)benzenes and 1-(1-arylvinyl)-2-(vinyloxy)benzenes for the synthesis of bis-difluoroalkylated benzoxepines I [R = H, 8-Me, 7-Cl, etc.; Ar = Ph, 4-MeC6H4, 2-thienyl, etc.] and 2H-chromenes II was developed. This method featured mild reaction conditions, good regioselectivity, a wide substrate scope, good functional-group compatibility, and late-stage modification. Preliminary mechanistic studies revealed that the generation of the CF2CO2Et radical is more prone to reaction with the double bond of the aryl group. In the experiment, the researchers used many compounds, for example, Ethylbromofluoroacetate(cas: 401-55-8Application In Synthesis of Ethylbromofluoroacetate)
Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application In Synthesis of Ethylbromofluoroacetate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary