《Design, synthesis and fungicidal activity of 3,4-dichloroisothiazolocoumarin-containing strobilurins》 was written by Lv, You; Li, Kun; Gao, Wei; Hao, Zesheng; Wang, Weibo; Liu, Xiaoyu; Tang, Liangfu; Fan, Zhijin. Application In Synthesis of Ethylbromofluoroacetate And the article was included in Molecular Diversity on April 30 ,2022. The article conveys some information:
Twenty-one novel 3,4-dichloroisothiazolocoumarin-containing strobilurins I (R1 = H, F, Cl, Me, Et; R2 = H, 6-Me, 8-Me, 8-Cl), II were rationally designed and synthesized. Preliminary bioassay showed that compounds I (R1 = H, R2 = 8-Cl (III); R1 = Cl, R2 = 6-Me; R1 = Me, R2 = 6-Me) exhibited over 80% inhibitory rate against Sclerotinia sclerotiorum at 50μg/mL, compound III exhibited good activity against S. sclerotiorum with median effective concentration (EC50) of 4.08μ/mL, while the pos. control coumoxystrobin showed EC50 of 1.00μg/mL. In addition, compound I (R1 = H, R2 = 6-Me) showed better fungicidal activity with a lower EC50 value of 7.65μg/mL against Botrytis cinerea than that of pos. control trifloxystrobin with its EC50 value of 21.96μg/mL. In this study, it was indicated that 3,4-dichloroisothiazolocoumarin-containing strobilurins I, II were promising fungicide lead deserved for further study. After reading the article, we found that the author used Ethylbromofluoroacetate(cas: 401-55-8Application In Synthesis of Ethylbromofluoroacetate)
Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application In Synthesis of Ethylbromofluoroacetate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary