Lehmann, Jonathan W. published the artcileAxial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids, Application In Synthesis of 452-63-1, the main research area is boronic acid preparation organobromine palladium regioselective enantioselective Suzuki coupling.
Ligand-based axial shielding of Pd(II) complexes enabled Suzuki-Miyaura cross-coupling of unactivated Csp3 boronic acids with perfect stereoretention was reported. This approach leverages key differences in spatial orientation between competing pathways for stereoretentive and stereoinvertive transmetalation of Csp3 boronic acids to Pd(II). The axial shielding enabled perfectly stereoretentive cross-coupling with a range of unactivated secondary Csp3 boronic acids, as well as the stereocontrolled synthesis of xylarinic acid B and all of its Csp3 stereoisomers. These ligand design principles will broadly enable the continued search for practical and effective methods for stereospecific Csp3 cross-coupling.
Nature Communications published new progress about Boronic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Application In Synthesis of 452-63-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary