Liang, Ren-Xiao published the artcileEnantioselective Pd-catalyzed dearomative reductive Heck and domino Heck-Suzuki reactions of 2-CF3-indoles, COA of Formula: C8H7BrO3, the main research area is isoindoloindolone asym synthesis; indole trifluoromethyl bromobenzoyl enantioselective dearomative reductive Heck; tetraarylborate enantioselective diastereoselective Heck Suzuki trifluoromethyl bromobenzoyl indole.
Highly enantioselective palladium-catalyzed dearomative reductive Heck reaction and domino Heck-Suzuki reaction of 2-CF3-indoles have been developed. In the presence of Pd(OAc)2/(R)-Synphos as the catalyst and Et3SiH as a hydride source, a variety of o-bromoaroyl indoles I (R1 = H, 5-MeO, 6-Cl, 6-F, 6-MeO; R2 = H, 4-F, 5-Me, 3,4-benzo, etc.) underwent a dearomative reductive Heck reaction to afford the corresponding indolines II (R3 = H) bearing a 2-trifluoromethyl quaternary stereocenter. Alternatively, using Pd(dba)2/phosphoramidite as the catalyst and R34BNa (R3 = Ph, 3-MeOC6H4, 1,3-benzodioxol-5-yl, etc.) as a coupling partner, structurally diverse indolines II containing two vicinal carbon stereocenters were obtained from I through domino dearomative Heck-Suzuki reaction.
Chemical Communications (Cambridge, United Kingdom) published new progress about Diastereoselective synthesis. 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, COA of Formula: C8H7BrO3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary