Medina, Jose M. published the artcileMizoroki-Heck Cyclizations of Amide Derivatives for the Introduction of Quaternary Centers, Name: 2-Bromo-4-methoxybenzoic acid, the main research area is alkenyl indanone chemoselective stereoselective preparation; nickel cyclohexylbenzimidazolium catalyst Mizoroki Heck cyclization alkenylbenzamide; Boc benzyl alkenylbenzamide chemoselective cyclization nickel cyclohexylbenzimidazolium catalyst; diastereoselective Heck cyclization methylbutenyl benzamide nickel catalyst; Mizoroki-Heck reactions; amides; homogeneous catalysis; nickel; quaternary centers.
In the presence of Ni(cod)2, a dicyclohexylbenzimidazolium chloride, and NaOt-Bu, alkenyl-substituted N-Boc-N-benzyl benzamides containing tri- or tetrasubstituted alkene moieties such as I underwent chemoselective Mizoroki-Heck cyclizations to yield α-alkenyl indanones such as II containing quaternary carbon centers in 51-93% average yields without decarbonylation. A dimethylbutenyl-substituted N-Boc-N-benzyl benzamide underwent diastereoselective Mizoroki-Heck cyclization to form a vinyldimethylindanone in 80% yield and in 92:8 dr.
Angewandte Chemie, International Edition published new progress about Aryl alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkenylbenzamides). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Name: 2-Bromo-4-methoxybenzoic acid.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary