Lindsay, Karl B. published the artcileFormal Total Synthesis of the Potent Renin Inhibitor Aliskiren: Application of a SmI2-Promoted Acyl-like Radical Coupling, Category: bromides-buliding-blocks, the main research area is renin inhibitor aliskiren total synthesis; samarium diiodide radical addition phenylalanine thioester acrylate.
A formal total synthesis of the potent renin inhibitor aliskiren is disclosed exploiting an alternative coupling strategy recently developed by the authors for the preparation of the hydroxyethylene isostere-based class of protease inhibitors. The 4-pyridyl thioester derivative of amino acid, CbzNHCH(CH2Ph)COS-Pyr (Pyr = 4-pyridyl), representing the C5-C9 fragment of the aliskiren carbon skeleton underwent a carbon chain extension via a SmI2-promoted radical addition to Bu acrylate. Introduction of the C3-iso-Pr group with the correct relative configuration was accomplished via stereoselective reduction of the obtained ketone with concomitant lactonization, followed by an aldol reaction with acetone. Further functional group and protecting group manipulation culminated in a formal total synthesis of aliskiren in 10 steps from the corresponding fully protected non-natural amino acid.
Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 172900-69-5 belongs to class bromides-buliding-blocks, name is 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene, and the molecular formula is C17H27BrO3, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary