Sun, Xicheng published the artcileDiscovery of S-Nitrosoglutathione Reductase Inhibitors: Potential Agents for the Treatment of Asthma and Other Inflammatory Diseases, HPLC of Formula: 1208318-08-4, the main research area is nitrosoglutathione reductase inhibitor preparation asthma inflammation; GSNO; GSNOR; N6022; asthma; nitric oxide; pyrrole.
S-Nitrosoglutathione reductase (GSNOR) regulates S-nitrosothiols (SNOs) and nitric oxide (NO) in vivo through catabolism of S-nitrosoglutathione (GSNO). GSNOR and the anti-inflammatory and smooth muscle relaxant activities of SNOs, GSNO, and NO play significant roles in pulmonary, cardiovascular, and gastrointestinal function. In GSNOR knockout mice, basal airway tone is reduced and the response to challenge with bronchoconstrictors or airway allergens is attenuated. Consequently, GSNOR has emerged as an attractive therapeutic target for several clin. important human diseases. As such, small mol. inhibitors of GSNOR were developed. These GSNOR inhibitors were potent, selective, and efficacious in animal models of inflammatory disease characterized by reduced levels of GSNO and bioavailable NO. N6022, a potent and reversible GSNOR inhibitor, reduced bronchoconstriction and pulmonary inflammation in a mouse model of asthma and demonstrated an acceptable safety profile. N6022 is currently in clin. development as a potential agent for the treatment of acute asthma.
ACS Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 1208318-08-4 belongs to class bromides-buliding-blocks, name is Ethyl 7-(4-bromophenyl)-4,7-dioxoheptanoate, and the molecular formula is C15H17BrO4, HPLC of Formula: 1208318-08-4.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary