Gotchev, Dimitar B. published the artcileSynthetic Studies Toward (-)-FR901483 Using a Conjugate Allylation To Install the C-1 Quaternary Carbon, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of Organic Chemistry (2006), 71(25), 9393-9402, database is CAplus and MEDLINE.
Two approaches to the aza-tricyclo dodecane skeleton of (-)-FR901483 are reported. Both routes utilized a Grignard addition to an N-acylpyridinium salt, e.g. from 4-methoxypyridine and PhOCOCl, to establish the absolute stereochem. at C-6 and a highly diastereoselective conjugate allylation reaction to form the quaternary center at C-1 of the natural product in an excellent yield. Although the desired polysubstituted piperidine intermediates, e.g. I, were prepared regio- and stereoselectively, the construction of the C-8/C-9 bond connectivity could not be achieved. All attempts at a pinacol cyclization or an intramol. 6-exo-tet epoxide opening were unsuccessful because of an unfavorable A(1,3) strain inherent in the mol.
Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary