Palmer, Wylie S. published the artcileDevelopment of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead, SDS of cas: 16523-02-7, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(5), 1486-1492, database is CAplus and MEDLINE.
A series of amino-pyrimidines was developed based upon an initial kinase cross-screening hit from a CDK2 program. Kinase profiling and structure-based drug design guided the optimization from the initial 1,2,3-benzotriazole hit to a potent and selective JNK inhibitor, compound 24f (JNK1 and 2 IC50 = 16 and 66 nM, resp.), with bioavailability in rats and suitable for further in vivo pharmacol. evaluation.
Bioorganic & Medicinal Chemistry Letters published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, SDS of cas: 16523-02-7.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary