Satz, Alexander Lee published the artcileDNA Compatible Multistep Synthesis and Applications to DNA Encoded Libraries, Formula: C9H7BrF3NO2, the publication is Bioconjugate Chemistry (2015), 26(8), 1623-1632, database is CAplus and MEDLINE.
Complex mixtures of DNA encoded small mols. may be readily interrogated via high-throughput sequencing. These DNA encoded libraries (DELs) are commonly used to discover mols. that interact with pharmaceutically relevant proteins. The chem. diversity displayed by the library is key to successful discovery of potent, novel, and drug-like chem. matter. The small mol. moieties of DELs are generally synthesized though a multistep process, and each chem. step is accomplished while it is simultaneously attached to an encoding DNA oligomer. Hence, library chem. diversity is often limited to DNA compatible synthetic reactions. Herein, protocols for 24 reactions are provided that have been optimized for high-throughput production of DELs. These protocols detail the multistep synthesis of benzimidazoles, imidazolidinones, quinazolinones, isoindolinones, thiazoles, and imidazopyridines. Addnl., protocols are provided for a diverse range of useful chem. reactions including BOC deprotection (under pH neutral conditions), carbamylation, and Sonogashira coupling. Last, step-by-step protocols for synthesizing functionalized DELs from trichloronitropyrimidine and trichloropyrimidine scaffolds are detailed.
Bioconjugate Chemistry published new progress about 1260672-86-3. 1260672-86-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is Methyl 2-(bromomethyl)-5-(trifluoromethyl)nicotinate, and the molecular formula is C9H7BrF3NO2, Formula: C9H7BrF3NO2.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary