Sokolsky, Alexander published the artcileSynthesis of a C(1)-C(23) Fragment for Spirastrellolide E: Development of a Mechanistic Rationale for Spiroketalization, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Organic Letters (2015), 17(8), 1898-1901, database is CAplus and MEDLINE.
Synthetic anal. of spirastrellolide E envisioned to entail a cross-metathesis union of the northern and southern hemispheres followed by a Sharpless epoxidation/methylation sequence to achieve the C(22,23) stereogenicity leads to the design of a C(1)-C(23) advanced southern hemisphere, I, exploiting a gold-catalyzed directed spiroketalization as a key step. Stereochem. anal. of this strategic transformation provides insight on the impact of the directing group carbinol stereogenicity on the reaction efficiency and, in turn, permits the conversion of the minor isomer of the spiroketal precursor to the requisite congener for successful spiroketalization.
Organic Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C13H16O2, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary