New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes was written by Dhimitruka, Ilirian;Eubank, Timothy D.;Gross, Amy C.;Khramtsov, Valery V.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Reference of 80480-15-5 The following contents are mentioned in the article:
A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often >100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors. This study involved multiple reactions and reactants, such as 2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5Reference of 80480-15-5).
2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 80480-15-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary