Laczkowski, K. Z. et al. published their research in Journal of Heterocyclic Chemistry in 2016 | CAS: 80480-15-5

2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Synthetic Route of C18H11BrO

Synthesis, Antimicrobial Activity and Molecular Docking Studies of 1,3-Thiazole Derivatives Incorporating Adamantanyl Moiety was written by Laczkowski, K. Z.;Misiura, K.;Biernasiuk, A.;Malm, A.;Paneth, A.;Plech, T.. And the article was included in Journal of Heterocyclic Chemistry in 2016.Synthetic Route of C18H11BrO The following contents are mentioned in the article:

Synthesis, characterization and study of antimicrobial activity of 11 novel adamantanyl-thiazoles are presented. Their structures were determined using 1H and 13C NMR, EI(+)-MS, HRMS, and elemental analyses. Among the derivatives, compound showed very strong activity, especially against Candida albicans ATCC 10231 and Candida parapsilosis ATCC 22019 with minimal inhibitory concentration (MIC) values ranging from 1.95 to 7.81 μg/mL. Compounds and showed good antifungal activity. Among the examined compounds, the widest spectrum of antibacterial activity possessed that showed good activity, especially against Staphylococcus epidermidis ATCC 12228, Micrococcus luteus ATCC 10240, Bacillus subtilis ATCC 6633 with MIC values ranging from 31.25 to 62.5 μg/mL. Mol. docking studies of all compounds on the active sites of microbial enzymes indicated possible targets sterol 14α-demethylase, secreted aspartic proteinase (SAP), N-myristoyltransferase (NMT), and topoisomerase II. Thiazoles showed more favorable affinity to SAP and NMT than the native ligand. This study involved multiple reactions and reactants, such as 2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5Synthetic Route of C18H11BrO).

2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Synthetic Route of C18H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary