Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB1 receptor was written by Moloney, Gerard P.;Angus, James A.;Robertson, Alan D.;Stoermer, Martin J.;Robinson, Michael;Wright, Christine E.;McRae, Ken;Christopoulos, Arthur. And the article was included in European Journal of Medicinal Chemistry in 2008.Application of 422560-40-5 The following contents are mentioned in the article:
An exploratory chem. effort has been undertaken to develop a novel series of compounds as selective CB1 agonists. It is hoped that compounds of this type will have clin. utility in pain control, and cerebral ischemia following stroke or traumatic head injury. Medicinal chem. studies directed towards the investigation of a series of 1-substituted-indole-3-oxadiazoles, e.g., I, as potential CB1 agonists have been disclosed. This study involved multiple reactions and reactants, such as 2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5Application of 422560-40-5).
2-(4-Bromophenyl)-N-hydroxyacetimidamide (cas: 422560-40-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 422560-40-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary