Fortuna, Andreia published the artcileSynthesis and Exploitation of the Biological Profile of Novel Guanidino Xylofuranose Derivatives, Name: 1-Bromododecane, the publication is ChemMedChem (2022), 17(14), e202200180, database is CAplus and MEDLINE.
The synthesis and biol. evaluation of novel guanidino sugars as iso-nucleoside analogs is described. 5-Guanidino xylofuranoses containing 3-O-saturated/unsaturated hydrocarbon or aromatic-containing moieties were accessed from 5-azido xylofuranoses via reduction followed by guanidinylation with N,N’-bis(tert-butoxycarbonyl)-N”-triflylguanidine. Mols. comprising novel types of iso-nucleosidic structures including 5-guanidino 3-O-methyl-branched N-benzyltriazole iso-nucleosides and a guanidinomethyltriazole 3′-O-dodecyl xylofuranos-5′-yl iso-nucleoside were accessed. The guanidinomethyl triazole derivative and a 3-O-dodecyl (N-Boc)guanidino xylofuranose were revealed as selective inhibitors of acetylcholinesterase (Ki=22.87 and 7.49μM, resp.). The latter also showed moderate antiproliferative effects in chronic myeloid leukemia (K562) and breast cancer (MCF-7) cells. An aminomethyltriazole 5′-iso-nucleoside was the most potent mol. with low micromolar GI50 values in both cells (GI50=6.33μM, 8.45μM), similar to that of the drug 5-fluorouracil in MCF-7 cells. Moreover, the most bioactive compounds showed low toxicity in human fibroblasts, further indicating their interest as promising lead mols.
ChemMedChem published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Name: 1-Bromododecane.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary