Behnke, Nicole Erin published the artcileTitanium-Mediated Synthesis of Spirocyclic NH-Azetidines from Oxime Ethers, Related Products of bromides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2019), 58(40), 14219-14223, database is CAplus and MEDLINE.
The TiIV-mediated synthesis of spirocyclic NH-azetidines from oxime ethers using either an alkyl Grignard reagent or terminal olefin ligand exchange coupling partner is described. Through a proposed Kulinkovich-type mechanism, a titanacyclopropane intermediate forms and serves as a 1,2-aliphatic dianion equivalent, inserting into the 1,2-dielectrophilic oxime ether to ultimately give rise to the desired N-heterocyclic four-membered ring. This transformation proceeds in moderate yield to furnish previously unreported and structurally diverse NH-azetidines in a single step. Thus, e.g., cyclohexanone O-methyloxime + phenethylmagnesium bromide → I (51%) in presence of Ti(Oi-Pr)4 in Et2O.
Angewandte Chemie, International Edition published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, Related Products of bromides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary