Nam, Doo H.’s team published research in Journal of Pharmaceutical Sciences in 73 | CAS: 56970-78-6

Journal of Pharmaceutical Sciences published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Safety of 3-Bromo-2-methylpropanoic acid.

Nam, Doo H. published the artcileAn improved synthesis of captopril, Safety of 3-Bromo-2-methylpropanoic acid, the publication is Journal of Pharmaceutical Sciences (1984), 73(12), 1843-4, database is CAplus and MEDLINE.

An improved synthesis of captopril using methacrylic acid as the starting material is described. Treatment of methacrylic acid with a hydrogen halide gave the 3-halogneo-2-methylpropanoic acids, which were treated with SOCl2 to yield the corresponding 3-halogeno-2-methylpropanoyl chlorides. Treatment of the chlorides with L-proline yielded the N-(R,S-3-halogeno-2-methylpropanoyl)-L-prolines (I, R = Br, Cl) (II) which were separated into optically pure R– and S-diastereoisomers using dicyclohexylamine. Treatment of (R)-II with methanolic NH4SH gave captopril (I, R = SH).

Journal of Pharmaceutical Sciences published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Safety of 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary