Harnden, Michael R. published the artcileSynthesis and antiviral activity of 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]purines, Recommanded Product: 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, the publication is Journal of Medicinal Chemistry (1987), 30(9), 1636-42, database is CAplus and MEDLINE.
Alkylation of 2-amino-6-chloropurine with 5-(2-bromoethyl)-2,2-dimethyl-1,3-dioxane provided 2-amino-6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl]purine (I) in high yield. I was readily converted to the antiviral acyclonucleoside II [R = NH2, R1 = R2 = H (III)] and to its 6-chloro, 6-thio, 6-alkoxy, 6-amino, and 6-deoxy purine analogs. III was also converted to its xanthine analog. Similarly, alkylation of 6-chloropurine provided a route to II (R = R1 = R2 = H).. Of these 9-substituted purines, III showed the highest activity against herpes simplex virus types 1 and 2 in cell cultures, and in some tests it was more active than acyclovir, with no evidence of toxicity for the cells. A series of monoesters and diesters of III were prepared, and some of these also showed antiherpes virus activity in cell cultures, the most active ester being the dihexanoate II [R = NH2, R1 = R2 = Me(CH2)4CO].
Journal of Medicinal Chemistry published new progress about 97845-58-4. 97845-58-4 belongs to bromides-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Bromide, name is 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, and the molecular formula is C8H15BrO2, Recommanded Product: 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary