Liu, Ping published the artcileDesign of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes, Product Details of C7H5Br2F, the publication is ACS Medicinal Chemistry Letters (2015), 6(8), 936-941, database is CAplus and MEDLINE.
The authors report herein the design and synthesis of a series of potent and selective GPR119 agonists. The objective was to develop a GPR119 agonist with properties that were suitable for fixed-dose combination with a DPP4 inhibitor. Starting from a phenoxy analog (1), medicinal chem. efforts directed toward reducing half-life and increasing solubility led to the synthesis of a series of benzyloxy analogs. Compound I was chosen for further profiling because of its favorable physicochem. properties and excellent GPR119 potency across species. This compound exhibited a clean off-target profile in counterscreens and good in vivo efficacy in mouse oGTT.
ACS Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Product Details of C7H5Br2F.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary