Bhuyan, Bhaskar J. published the artcileSynthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors, Formula: C4H7BrO2, the publication is Organic & Biomolecular Chemistry (2011), 9(5), 1356-1365, database is CAplus and MEDLINE.
Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I (Ang I) to angiotensin II (Ang II). ACE also cleaves the terminal dipeptide of vasodilating hormone bradykinin (a nonapeptide) to inactivate this hormone. Therefore, inhibition of ACE is generally used as one of the methods for the treatment of hypertension. Oxidative stress’ is another disease state caused by an imbalance in the production of oxidants and antioxidants. A number of studies suggest that hypertension and oxidative stress are interdependent. Therefore, ACE inhibitors having antioxidant property are considered beneficial for the treatment of hypertension. As selenium compounds are known to exhibit better antioxidant behavior than their sulfur analogs, we have synthesized a number of selenium analogs of captopril, an ACE inhibitor used as an antihypertensive drug. The selenium analogs of captopril not only inhibit ACE activity but also effectively scavenge peroxynitrite, a strong oxidant found in vivo.
Organic & Biomolecular Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Formula: C4H7BrO2.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary