Camp, David published the artcileDevelopment of a Synthetic Process towards a Hepatitis C Polymerase Inhibitor, SDS of cas: 76283-09-5, the publication is Organic Process Research & Development (2006), 10(4), 814-821, database is CAplus.
The synthesis of clin. candidate 2-(4-{2-[(2R)-2-Cyclopentyl-5-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylmethyl)-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]-ethyl}-2-fluoro-phenyl)-2-methyl-propionitrile (I) on multikilogram scale is described. Initial synthesis of I, clin. candidate for inhibition of the hepatitis C viral polymerase (HCVP) protein, was executed via a racemic synthetic route coupled with chiral HPLC separation Due to the achiral route and instability of key intermediates, the initial route was determined to be unsuitable for large-scale manufacture An alternate route was developed utilizing a convergent Heck coupling, resolution of a carboxylic acid via diastereomeric salt formation, and an efficient chem. recycling of the undesired enantiomer.
Organic Process Research & Development published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, SDS of cas: 76283-09-5.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary