Dalkas, Georgios A. published the artcileStudy of a lipophilic captopril analogue binding to angiotensin I converting enzyme, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is Journal of Peptide Science (2010), 16(2), 91-97, database is CAplus and MEDLINE.
Human ACE is a central component of the renin-angiotensin system and a major therapeutic target for cardiovascular diseases. The somatic form of the enzyme (sACE) comprises two homologous metallopeptidase domains (N and C), each bearing a zinc active site with similar but distinct substrate and inhibitor specificities. In this study, we present the biol. activity of silacaptopril, a silylated analog of captopril, and its binding affinity towards ACE. Based on the recently determined crystal structures of both the ACE domains, a series of docking calculations were carried out in order to study the structural characteristics and the binding properties of silacaptopril and its analogs with ACE. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.
Journal of Peptide Science published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Recommanded Product: 3-Bromo-2-methylpropanoic acid.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary