Miller, Joseph A.’s team published research in Israel Journal of Chemistry in 24 | CAS: 69361-41-7

Israel Journal of Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Miller, Joseph A. published the artcileControlled carbometalation. 17. Cyclic carboalumination of alkynylsilanes forming exocyclic alkenes, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Israel Journal of Chemistry (1984), 24(2), 76-81, database is CAplus.

The reaction of Me3SiCC(CH2)nCH:CH2 (I; n = 2, 3) with 1.1 equivalent and catalytic Cp2ZrCl2 (Cp = cyclopentadienyl) in ClCH2CH2Cl or CH2Cl2 at room temperature gave methylenecycloalkanes II (R = H, n = 2, 3) in 72-85% yield after hydrolysis, and iodinolysis gave 68% II (R = iodo, n = 2). However, I (n = 1, 4) did not cyclize under the same conditions. Whereas Al(CH2CHMe2)3-Cp2ZrCl2 cyclization of Me3SiCCCHR1CH2CH:CH2 III; (R1 = Me) gave 1:1 methylenecyclopentanes (Z)-IV and (E)-V, using Cp2ZrI2 rather than Cp2ZrCl2, or using Al(CH2CHMe2)3-Al(CH2CHMe2)2OMe-Cp2ZrCl2, gave 20:80 IV–V. The reaction of III (R1 = OH) with Al(CH2CHMe2)3-Cp2ZrCl2 under kinetic conditions gave 82% product containing 90% IV whereas under thermal equilibration 74% product containing 97% V was formed.

Israel Journal of Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary