Nachtergaele, Sigrid published the artcileOxysterols are allosteric activators of the oncoprotein Smoothened, SDS of cas: 69361-41-7, the publication is Nature Chemical Biology (2012), 8(2), 211-220, database is CAplus and MEDLINE.
Oxysterols are a class of endogenous signaling mols. that can activate the Hedgehog pathway, which has critical roles in development, regeneration and cancer. However, it has been unclear how oxysterols influence Hedgehog signaling, including whether their effects are mediated through a protein target or indirectly through effects on membrane properties. To answer this question, we synthesized the enantiomer and an epimer of the most potent oxysterol, 20(S)-hydroxycholesterol. Using these mols., we show that the effects of oxysterols on Hedgehog signaling are exquisitely stereoselective, consistent with the hypothesis that they function through a specific protein target. We present several lines of evidence that this protein target is the seven-pass transmembrane protein Smoothened (Smo), a major drug target in oncol. Our work suggests that these enigmatic sterols, which have multiple effects on cell physiol., may act as ligands for signaling receptors and provides a generally applicable framework for probing sterol signaling mechanisms.
Nature Chemical Biology published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, SDS of cas: 69361-41-7.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary