Month: November 2022

Omar, Hanaa S.; Abd El-Rahman, Soheir N.; AlGhannam, Sheikha M.; Sedeek, Mohamed S. published an article in 2021. The article was titled 《Antifungal Evaluation and Molecular Docking Studies of Olea europaea Leaf Extract, Thymus vulgaris and Boswellia carteri Essential Oil as Prospective Fungal Inhibitor Candidates》, and you may find the article in Molecules.Product Details of 4316-58-9 The information in the text is summarized as follows:

The present study investigated the antifungal activity and mode of action of four Olea europaea leaf extracts, Thymus vulgaris essential oil (EO), and Boswellia carteri EO against Fusarium oxysporum. Fusarium oxysporum Lactucae was detected with the internal transcribed spacer (ITS) region. The chem. compositions of chloroform and dichloromethane extracts of O. europaea leaves and T. vulgaris EO were analyzed using GC-MS anal. In addition, a mol. docking anal. was used to identify the expected ligands of these extracts against eleven F. oxysporum proteins. The nucleotide sequence of the F. oxysporum Lactucae isolate was deposited in GenBank with Accession NumberMT249304.1. The T. vulgaris EO, chloroform, dichloromethane and ethanol efficiently inhibited the growth at concentrations of 75.5 and 37.75 mg/mL, whereas Et acetate, and B. carteri EO did not exhibit antifungal activity. The GC-MS anal. revealed that the major and most vital compounds of the T. vulgaris EO, chloroform, and dichloromethane were thymol, carvacrol, tetratriacontane, and palmitic acid. Moreover, mol. modeling revealed the activity of these compounds against F. oxysporum. Chloroform, dichloromethane and ethanol, olive leaf extract, and T. vulgaris EO showed a strong effect against F. oxysporum. Consequently, this represents an appropriate natural source of biol. compounds for use in healthcare. In addition, homol. modeling and docking anal. are the best analyses for clarifying the mechanisms of antifungal activity. In the experiment, the researchers used many compounds, for example, Tris(4-bromophenyl)amine(cas: 4316-58-9Product Details of 4316-58-9)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Product Details of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Jinqing; Zhong, Hong; Lv, Haowei; Liu, Ruixia; Wang, Ruihu published an article in 2021. The article was titled 《Regulating Utilization Efficiency of the Photogenerated Charge Carriers by Constructing Donor-π-Acceptor Polymers for Upgrading Photocatalytic CO2 Reduction》, and you may find the article in ChemSusChem.Computed Properties of C14H8Br2 The information in the text is summarized as follows:

Photocatalytic CO2 reduction offers a promising approach for managing global carbon balance. The smooth delivery of the photoexcited electrons to the active sites without the extra photosensitizers is still challenging. Herein, a series of donor-π-acceptor conjugated organic polymers (COPs) were produced using anthracene, cobalt-coordinated bipyridyl, and benzene as donor, acceptor, and π linker units, resp. The introduction of Ph linker significantly improved the activities of photocatalytic CO2 reduction upon visible light illumination. Structure-performance relationship examinations uncovered that donor-π-acceptor structure promotes mobility of charge carriers and utilization efficiency on the catalytically active sites, resulting in high photocatalytic activity and durability for CO2 photoreduction The in-depth insights into the electron transport processes open new perspectives for further optimization and rational design of photoactive polymers with high efficiency for solar-energy conversion.9,10-Dibromoanthracene(cas: 523-27-3Computed Properties of C14H8Br2) was used in this study.

9,10-Dibromoanthracene(cas: 523-27-3) is a dibrominated polycyclic aromatic hydrocarbon (PAH). 9,10-Dibromoanthracene is often used as an energy acceptor and activator in reactions that produce chemiluminescence.Computed Properties of C14H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Meng, He; Bai, Shiming; Qiao, Yu; He, Ting; Li, Weiyi; Ming, Jialin published an article in 2022. The article was titled 《Rhodium-Catalyzed Three-Component Reaction of Alkynes, Arylzinc Chlorides, and Iodomethanes Producing Trisubstituted/Tetrasubstituted Alkenes with/without 1,4-Migration》, and you may find the article in Organic Letters.Synthetic Route of C7H5BrO2 The information in the text is summarized as follows:

A three-component reaction of alkynes, arylzinc chlorides and iodomethanes was found to proceed in the presence of a rhodium catalyst to give high yields of trisubstituted/tetrasubstituted alkenes I [R = 2-MeC6H4, 2-Me-4-MeOC6H3, 2-furyl, etc.; R1 = H, Me; R2 = Me, n-Pr, (CH2)4I, etc.; R3 = Me, n-Pr, (CH2)3OMe, etc.; R2R3 = (CH2)10]. The usual arylzinc chlorides only gave trisubstituted alkenes, generated through a migratory carbozincation-cross-coupling sequence, where 1,4-Rh migration from an alkenyl carbon to an aryl carbon occurred. In contrast, 5-membered heteroarylzinc chlorides only gave the tetrasubstituted alkenes via a carborhodation-cross-coupling pathway without 1,4-migration. The experimental part of the paper was very detailed, including the reaction process of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Synthetic Route of C7H5BrO2)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Synthetic Route of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Li, Zhao; Yang, Yuan; Yin, Pei; Yang, Zengming; Zhang, Bo; Zhang, Shengjun; Han, Bingyang; Lv, Jiawei; Dong, Fenghao; Ma, Hengchang published an article in ChemistrySelect. The title of the article was 《A New Lipid-Droplets-Targeted Fluorescence Probe with Dual-Reactive Sites for Specific Detection of ClO- in Living Cells》.COA of Formula: C18H12Br3N The author mentioned the following in the article:

Lipid droplets (LDs) are organelles composed of a lipid core surrounded by a phospholipid monolayer, plays an important role in a variety of physiol. processes as well as diseases. In this work, TPAs-SCH3-2CN with an enhanced electron D-π-A system, is synthesized, which makes itself as an orange emission compound (Em=590 nm) and also have high polarity. It is verified that TPAs-SCH3-2CN is an excellent LDs-targeted probe, and it also sensitive to the ClO- detection in vitro and in cells. Impressively, due to the high lipophilicity, TPAs-SCH3-2CN is able to stain the yolk lipids in zebrafish, exhibiting the potential for monitoring lipid transport and metabolism processes. In the experiment, the researchers used Tris(4-bromophenyl)amine(cas: 4316-58-9COA of Formula: C18H12Br3N)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)COA of Formula: C18H12Br3N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Trunks, Thomas M.; Babra, Jasraj Singh; Westwood, James; Smith, Christopher D. published an article in SynOpen. The title of the article was 《A Homocoupling Approach to the Key Dione of CyMe 4-BTPhen-Vital Ligands for Nuclear Clean-Up by the SANEX Process》.Safety of Ethyl 3-bromopropanoate The author mentioned the following in the article:

The synthesis of the CyMe4 fragment beginning from readily available hydroxypivalic acid. It featured a cobalt-catalyzed homocoupling of a neopentyl bromide to provided the key bisester precursor, thereby avoiding the requirement for tech. challenging low-temperature LDA-mediated aldol chemistries. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-bromopropanoate(cas: 539-74-2Safety of Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Safety of Ethyl 3-bromopropanoate Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Hongquan; Wen, Chunxi; Li, Bingting; Yan, Xinlin; Xu, Yangrong; Guo, Jialin; Hou, Shi; Chang, Jiajia; Li, Song; Xiao, Junhai published an article in Molecules. The title of the article was 《Phenoxyaromatic Acid Analogues as Novel Radiotherapy Sensitizers: Design, Synthesis and Biological Evaluation》.Formula: C6H5Br2N The author mentioned the following in the article:

Radiotherapy is a vital approach for brain tumor treatment. The standard treatment for glioblastoma (GB) is maximal surgical resection combined with radiotherapy and chemotherapy. However, the non-sensitivity of tumor cells in the hypoxic area of solid tumors to radiotherapy may cause radioresistance. Therefore, radiotherapy sensitizers that increase the oxygen concentration within the tumor are promising for increasing the effectiveness of radiation. Inspired by Hb allosteric oxygen release regulators, a series of novel phenoxyacetic acid analogs were designed and synthesized. A numerical method was applied to determine the activity and safety of newly synthesized compounds In vitro studies on the evaluation of red blood cells revealed that compounds 19c (ΔP50 = 45.50 mmHg) and 19t (ΔP50 = 44.38 mmHg) improve the oxygen-releasing property effectively compared to pos. control efaproxiral (ΔP50 = 36.40 mmHg). Preliminary safety evaluation revealed that 19c exhibited no cytotoxicity towards HEK293 and U87MG cells, while 19t was cytotoxic toward both cells with no selectivity. An in vivo activity assay confirmed that 19c exhibited a radiosensitization effect on orthotopically transplanted GB in mouse brains. Moreover, a pharmacokinetic study in rats showed that 19c was orally available. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Formula: C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Bonfant, Giulia; Balestri, Davide; Perego, Jacopo; Comotti, Angiolina; Bracco, Silvia; Koepf, Matthieu; Gennari, Marcello; Marchio, Luciano published an article in ACS Omega. The title of the article was 《Phosphine Oxide Porous Organic Polymers Incorporating Cobalt(II) Ions: Synthesis, Characterization, and Investigation of H2 Production》.COA of Formula: C8H8Br2 The author mentioned the following in the article:

Suitably functionalized porous matrixes represent versatile platforms to support well-dispersed catalytic centers. In the present study, porous organic polymers (POPs) containing phosphine oxide groups were fabricated to bind transition metals and to be investigated for potential electrocatalytic applications. Crosslinking of mono- and di-phosphine monomers with multiple Ph substituents was subject to the Friedel-Crafts (F-C) reaction and the oxidation process, which generated phosphine oxide porous polymers with pore capacity up to 0.92 cm3/g and a surface area of about 990 m2/g. The formation of the R3P·BH3 borohydride adduct during synthesis allows to extend the library of phosphine-based monomeric entities when using FeCl3. The porous polymers were loaded with 0.8-4.2 weight/weight % of cobalt(II) and behaved as hydrogen evolution reaction (HER) catalysts with a Faradaic efficiency of up to 95% (5.81 x 10-5 mol H2 per 11.76 C) and a stable c.d. during repeated controlled potential experiments (CPE), even though with high overpotentials (0.53-0.68 V to reach a c.d. of 1 mA·cm-2). These studies open the way to the effectiveness of tailored phosphine oxide POPs produced through an inexpensive and ecofriendly iron-based catalyst and for the insertion of transition metals in a porous architecture, enabling electrochem. driven activation of small mols. The experimental part of the paper was very detailed, including the reaction process of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5COA of Formula: C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. COA of Formula: C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C12H7Br2NIn 2022 ,《Occurrence and distribution of polyhalogenated carbazoles in eastern Tibetan Plateau soils along the slope of Mt. Qionglai》 appeared in Chemosphere. The author of the article were Liu, Mingkai; Huang, Longhua; Li, Xiaoshuang; Liu, Fei; Zhang, Wei; Wang, Zhe; Xu, Yan; Ke, Runhui; He, Hongping; Lou, Yinghua. The article conveys some information:

Polyhalogenated carbazoles (PHCZs), are considered as potential persistent organic pollutants (POPs), which have been frequently detected in the environment. However, the altitudinal distribution characteristics and possible sources of PHCZs in high mountain soils are still unknown. The present study was the first to analyze PHCZs in soil samples collected along the eastern slope of Mt. Qionglai (MQ), the east edge of the Tibetan Plateau. The concentration of ΣPHCZs (based on dry weight) ranges from 14.4 to 107 ng/g (median value of 40.9), which was at high end of the range reported in soils and sediments to date in the literature. The composition profiles of PHCZs in the soils of MQ were dominated by 3,6-dichlorocarbazole (36-CCZ), 3-chlorocarbazole (3-CCZ), and 2-bromocarbazole (2-BCZ). The mean TOC-normalized concentrations of ΣPHCZs in soil samples from below-treeline (2092 ng/g TOC) were higher than those from alpine meadow (1124 ng/g TOC), probably due to the forest filter effect. The decreasing trend of the PHCZs TOC-normalized concentrations with altitude shows that accumulation of PHCZs from the alpine meadow samples was not affected by the mountain cold-trapping effect. Significantly pos. correlations were observed between the concentrations of more than half of detected PHCZ congeners and TOC. In addition, PHCZs show the potential to represent a class of POPs with the frequent occurrence and wide distribution, as the abundance and environmental behavior of PHCZs are similar to some POPs in MQ. In the experimental materials used by the author, we found 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Formula: C12H7Br2N)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Formula: C12H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: Br3InIn 2020 ,《In Situ Transmission Electron Microscopy Measurements of Ge Nanowire Synthesis with Liquid Metal Nanodroplets in Water》 was published in ACS Nano. The article was written by Cheek, Quintin; Fahrenkrug, Eli; Hlynchuk, Sofiya; Alsem, Daan Hein; Salmon, Norman J.; Maldonado, Stephen. The article contains the following contents:

The growth of Ge nanowires in water inside a liquid transmission electron microscope (TEM) holder has been demonstrated at room temperature Each nanowire growth event was stimulated by the incident electron beam on otherwise unsupported liquid Ga or liquid In nanodroplets. A variety of conditions were explored, including liquid metal nanodroplet surface condition, liquid metal nanodroplet size and d., formal concentration of dissolved GeO2, and electron beam intensity. The cumulative observations from a series of videos recorded during growth events suggested the following points. First, the conditions necessary for initiating nanowire growth at uncontacted liquid metal nanodroplets in a liquid TEM cell indicate the process was governed by solvated electrons generated from secondary electrons scattered by the liquid metal nanodroplets. The attained current densities were comparable to those achieved in conventional electrochem. liquid-liquid-solid (ec-LLS) growths outside of a TEM. Second, the surface condition of the liquid metal nanodroplets was quite influential on whether nanowire growth occurred and surface diffusion of Ge adatoms contributed to the rate of crystallization Third, the Ge nanowire growth rates were limited by the feed rate of Ge to the crystal growth front rather than the rate of crystallization at the liquid metal/solid Ge interface. Estimates of an electrochem. current for the reduction of dissolved GeO2 were nominally in line with currents used for Ge nanowire growth by ec-LLS outside of the TEM. Fourth, the Ge nanowire growths in the liquid TEM cell occurred far from thermodn. equilibrium, with supersaturation values of 104 prior to nucleation. These collective points provide insight on how to further control and improve Ge nanowire morphol. and crystallog. quality by the ec-LLS method.Indium(III) bromide(cas: 13465-09-3Formula: Br3In) was used in this study.

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Formula: Br3In

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 7073-94-1In 2020 ,《C-H Arylation of Thiophenes with Aryl Bromides by a Parts-per-Million Loading of a Palladium NNC-Pincer Complex》 was published in Synlett. The article was written by Purta, Anggi Eka; Ichii, Shun; Tazawa, Aya; Uozumi, Yasuhiro. The article contains the following contents:

A palladium NNC-pincer complex efficiently catalyzed the direct arylation of thiophene derivatives with extremely low palladium loadings of the order of ppm. Thus, the reaction of various thiophenes with aryl bromides in the presence of 25-100 mol ppm of chlorido[(2-phenyl-κ- C2)-9-phenyl-1,10-phenanthroline-κ2-N,N’]palladium(II) NNC-pincer complex, K 2CO3 and pivalic acid in N,N-dimethylacetamide afforded the corresponding 2- or 5-arylated thiophenes I [R1 = H, 5-Cl, 5-Me; Ar = Ph, 4-MeC6H4, 1-naphthyl, etc.] and II [R = 2-Cl, 2-Me, 2-Ph-3-Me, etc.; Ar = 4-MeC6H4] in good to excellent yields. A combination of the present C-H arylation and Hiyama coupling with the same NNC-pincer complex provided an efficient synthesis of unsym. 2,5-thiophenes II [R = 2-(4-MeOC6H4), 2-(4-F3CC6H4); Ar = 4-MeC6H4] with catalyst loadings at mol ppm levels. In the experiment, the researchers used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1HPLC of Formula: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. HPLC of Formula: 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary