Month: November 2022

In 2019,Chemical Science included an article by Nguyen, Julia; Chong, Andrea; Lalic, Gojko. SDS of cas: 1779-49-3. The article was titled 《Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes》. The information in the text is summarized as follows:

We have developed a nickel-catalyzed hydroarylation of alkenes using aryl halides as coupling partners. Excellent anti-Markovnikov selectivity is achieved with aryl-substituted alkenes and enol ethers. We also show that hydroarylation occurs with alkyl substituted alkenes to yield linear products. Preliminary examination of the reaction mechanism suggests irreversible hydrometallation as the selectivity determining step of the hydroarylation. After reading the article, we found that the author used Methyltriphenylphosphonium bromide(cas: 1779-49-3SDS of cas: 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. SDS of cas: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Dalton Transactions included an article by Gong, Dawei; Hu, Bowen; Chen, Dafa. COA of Formula: C7H5BrO2. The article was titled 《Bidentate Ru(II)-NC complexes as catalysts for the dehydrogenative reaction from primary alcohols to carboxylic acids》. The information in the text is summarized as follows:

Four Ru(II)-NC complexes were synthesized by one-step processes from the corresponding NC ligands with RuHCl(CO)(PPh3)3. These complexes were tested as catalysts for alc. dehydrogenative reactions, and complex {(C5H4N)-(C6H4)}RuCl(CO)(PPh3)2 (1) showed the highest activity. With KOH as the nucleophile and 0.5 mol% catalyst loading, a series of carboxylic acids were synthesized in toluene without any oxidant. Catalyst 1 could be transformed to complex {(C5H4N)-(C6H4)}RuH(CO)(PPh3)2 (6) when treated with KOH and benzyl alc. Complex 6 further reacted with PhCHO and H2O to generate product {(C5H4N)-(C6H4)}Ru(OCOPh)(CO)(PPh3)2 (7). Complexes 6 and 7 exhibited similar efficiency to complex 1, suggesting that they can be regarded as the catalytic intermediates of. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzoic acid(cas: 586-76-5COA of Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.COA of Formula: C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Organic Letters included an article by Rocaboy, Ronan; Baudoin, Olivier. Recommanded Product: 6630-33-7. The article was titled 《1,4-Palladium Shift/C(sp3)-H Activation Strategy for the Remote Construction of Five-Membered Rings》. The information in the text is summarized as follows:

1,N-Metal shift is an elegant alternative approach enabling the functionalization of remote C-H bonds from simple precursors. In this work, a novel and simple Pd0-catalyzed domino reaction involving 1,4-palladium shift and C(sp3)-H activation and leading to (fused) five-membered rings is reported. This method allowed access to a broad range of valuable arylidene γ-lactams and indanones and was applied to the formal synthesis of (-)-pyrrolam A. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Recommanded Product: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Recommanded Product: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ACS Catalysis included an article by Hemric, Brett N.; Chen, Andy W.; Wang, Qiu. Recommanded Product: 1779-49-3. The article was titled 《Copper-Catalyzed 1,2-Amino Oxygenation of 1,3-Dienes: A Chemo-, Regio-, and Site-Selective Three-Component Reaction with O-Acylhydroxylamines and Carboxylic Acids》. The information in the text is summarized as follows:

A three-component reaction for 1,2-amino oxygenation of 1,3-dienes has been achieved using O-acyl hydroxylamines and carboxylic acids. The reaction occurs through copper-catalyzed amination of olefins followed by nucleophilic addition of carboxylic acids, offering high levels of chemo-, regio-, and site-selectivity. The method is effective for both terminal and internal 1,3-dienes, including those bearing multiple, unsym. substituents. The amino oxygenation conditions also exhibited remarkable selectivity toward 1,3-dienes over alkenes, good tolerance of sensitive functional groups, and reliable scalability. In the experiment, the researchers used Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis. And it is used widely for methylenation via the Wittig reaction.Recommanded Product: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Nickel-Catalyzed Transformation of Diazoacetates to Alkyl Radicals Using Alcohol as a Hydrogen Source》 were Zhao, Jingjing; Li, Pan; Xu, Yaohua; Shi, Yixin; Li, Fuwei. And the article was published in Organic Letters in 2019. Name: Benzyl 2-bromoacetate The author mentioned the following in the article:

A nickel-catalyzed transformation of diazoacetates to α-carbonyl methylene radicals has been disclosed in the presence of hyperoxide using ethanol as a hydrogen source and solvent. This strategy is successfully applied in the formation of indolin-2-ones or 1,4-dicarbonyl compounds from acrylamides or enamides in moderate to good yields. These reactions underwent radical addition onto C-C double bonds followed by a cyclization/oxidation or an oxidation/hydrolysis process, resp. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Name: Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Name: Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Fe/Fe3C Encapsulated in N-Doped Carbon Tubes: A Recyclable Catalyst for Hydrogenation with High Selectivity》 were Yun, Ruirui; Zhang, Shi; Ma, Wanjiao; Lv, Xiao; Liu, Shoujie; Sheng, Tian; Wang, Suna. And the article was published in Inorganic Chemistry in 2019. Product Details of 626-40-4 The author mentioned the following in the article:

Herein, a series of Fe-based catalysts have been designed and prepared by grinding a mixture of MIL-88d and melamine, and then the mixture was followed by pyrolysis. An unusual Fe/Fe3C-activated site is uniformly encapsulated in the N-doped carbon tubes obtained by pyrolysis of the film-like nanocrystals of MIL-88d. Exptl. characterizations and theor. calculations demonstrate that the surface N sites can effectively trap the nitrobenzene and aniline by their Ph groups with the formation of three C-N bonds that made the catalyst exhibit excellent catalytic activity (turnover frequencies of ≤11268 h-1 calculated on the basis of nitrobenzene) and chemoselectivity for the reduction of nitro derivatives under facile conditions. In the experiment, the researchers used many compounds, for example, 3,5-Dibromoaniline(cas: 626-40-4Product Details of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Product Details of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Ladderization of polystyrene derivatives by palladium-catalyzed polymer direct arylation》 were Takagi, Koji; Tanaka, Hidetoshi; Mikami, Koichiro. And the article was published in Polymer Chemistry in 2019. SDS of cas: 1779-49-3 The author mentioned the following in the article:

Ladderization of polystyrene derivatives successfully proceeded by palladium-catalyzed polymer direct arylation in the presence of a phosphine ligand and pivalic acid using poly(2-bromostyrene) as a prepolymer, in which the polymer tacticity had little influence on the reaction efficiency. The reaction mechanism was supported by theor. calculation in detail. The optical and thermal properties of pseudo-ladderized polystyrene suggested enhanced chain rigidity. The experimental process involved the reaction of Methyltriphenylphosphonium bromide(cas: 1779-49-3SDS of cas: 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis. And it is used widely for methylenation via the Wittig reaction.SDS of cas: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Funneling aromatic products of chemically depolymerized lignin into 2-pyrone-4-6-dicarboxylic acid with Novosphingobium aromaticivorans》 were Perez, Jose M.; Kontur, Wayne S.; Alherech, Manar; Coplien, Jason; Karlen, Steven D.; Stahl, Shannon S.; Donohue, Timothy J.; Noguera, Daniel R.. And the article was published in Green Chemistry in 2019. Electric Literature of C20H20BrP The author mentioned the following in the article:

Lignin is an aromatic heteropolymer found in plant biomass. Depolymerization of lignin, either through biol. or chem. means, invariably produces heterogenous mixtures of low mol. weight aromatic compounds Microbes that can metabolize lignin-derived aromatics have evolved pathways that funnel these heterogeneous mixtures into a few common intermediates before opening the aromatic ring. In this work, we engineered Novosphingobium aromaticivorans DSM12444, via targeted gene deletions, to use its native funneling pathways to simultaneously convert plant-derived aromatic compounds containing syringyl (S), guaiacyl (G), and p-hydroxyphenyl (H) aromatic units into 2-pyrone-4,6-dicarboxylic acid (PDC), a potential polyester precursor. In batch cultures containing defined media, the engineered strain converted several of these depolymerization products, including S-diketone and G-diketone (non-natural compounds specifically produced by chem. depolymerization), into PDC with yields ranging from 22% to 100%. In batch cultures containing a heterogeneous mixture of aromatic monomers derived from chem. depolymerization of poplar lignin, 59% of the measured aromatic compounds were converted to PDC. Overall, our results show that N. aromaticivorans has ideal characteristics for its use as a microbial platform for funneling heterogeneous mixtures of lignin depolymerization products into PDC or other commodity chems. The experimental part of the paper was very detailed, including the reaction process of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Electric Literature of C20H20BrP)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Electric Literature of C20H20BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold》 were Li, Zheng; Ren, Qiang; Wang, Xuekun; Zhou, Zongtao; Hu, Lijun; Deng, Liming; Guan, Li; Qiu, Qianqian. And the article was published in Bioorganic Chemistry in 2019. Application of 7051-34-5 The author mentioned the following in the article:

Based on a previously reported phenoxyacetic acid scaffold, compound 7 (HWL-088) has been identified as a superior free fatty acid receptor 1 (FFA1) agonist by comprehensive structure-activity relationship study. Our results indicated that the introduction of ortho-fluoro greatly increased the activity of phenoxyacetic acid series, and the unique structure-activity relationship in biphenyl moiety is different from previously reported FFA1 agonists. Moreover, the modeling study was also performed to better understand the binding mode of present series. Compound 7 significantly improved glucose tolerance both in normal and diabetic models, and even exerted greater potential on glucose control than that of TAK-875. These findings provided a novel candidate HWL-088, which is currently in preclin. study to evaluate its potential for the treatment of diabetes. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis, properties and photo-responsive behavior of luminescent side chain polymers containing D-π-A α-cyanostilbene units》 were Yuan, Yongjie; He, Lifang; Li, Jindi; Zhang, Hailiang. And the article was published in Polymer Chemistry in 2019. HPLC of Formula: 629-03-8 The author mentioned the following in the article:

A series of luminescent side chain polymers containing a D-π-A structure and different flexible spacer lengths, namely, poly[(Z)-ω-(4-(1-cyano-2-(4-cyanophenyl)vinyl)phenoxy)alkyl methacrylate]s (PMmPVPCN, m = 2, 4, 6, 8), were successfully prepared With the combination of aggregation-induced emission enhancement (AIEE) luminogens and mesogens, the resultant polymers are expected to possess both liquid crystal characteristics and AIEE characteristics. The phase structure of PMmPVPCN was explored by differential scanning calorimetry (DSC), polarized optical microscopy (POM), and one-dimensional wide-angle X-ray diffraction (1D WAXD). Photophys. properties of PMmPVPCN were studied by UV spectra and fluorescence spectra. Test results suggested that the phase structure of PMmPVPCN transformed from the amorphous phase (PMmPVPCN, m = 2, 4) to the nematic phase (PMmPVPCN, m = 6, 8) with the increase of polymer spacer length. All the synthetic monomers and polymers exhibited AIEE properties and the luminescence behavior of PMmPVPCN was associated with their chem. structure. The solid fluorescence quantum yields of PMmPVPCN increased from 22.4% to 42.7% with increasing spacer length. The polymer films also showed reversible fluorescence photo-responsive properties. The emission color and the emission intensity of polymer films changed when exposed to a 365 nm UV lamp. The change process was reversible and they could turn back to their original state when irradiated with a 254 nm UV lamp or heated at higher temperature In the experiment, the researchers used 1,6-Dibromohexane(cas: 629-03-8HPLC of Formula: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.HPLC of Formula: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary