Month: November 2022

《Rapid synthesis of acyl fluorides from carboxylic acids with Cu(O2CCF2SO2F)2》 was published in Tetrahedron Letters in 2020. These research results belong to Le, Bingjun; Wu, Hao; Hu, Xiaojun; Zhou, Xiumiao; Guo, Yong; Chen, Qing-Yun; Liu, Chao. Recommanded Product: 4-Bromobenzoic acid The article mentions the following:

A rapid, simple and efficient acyl fluoride RC(O)F [R = Ph, Bn, 2-thienyl, etc.] synthesis from carboxylic acids with Cu(O2CCF2SO2F)2 as a deoxofluorination reagent was developed. Notably, Cu(O2CCF2SO2F)2 was readily prepared in large scale from inexpensive starting material and previously used as a good trifluoromethylating reagent. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 4-Bromobenzoic acid It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Highly Selective and Atom Economical Synthesis of 1,3-Enynes, Pyrroles and Furans by Manganese(I)-Catalyzed C-H Activation》 was published in ACS Catalysis in 2020. These research results belong to Cembellin, Sara; Dalton, Toryn; Pinkert, Tobias; Schaefers, Felix; Glorius, Frank. HPLC of Formula: 14516-54-2 The article mentions the following:

A highly selective Mn(I)-catalyzed alkenylation of arenes and heteroarenes with 1,3-diynes is described. The reported transformation overcomes regio-, chemo- and stereoselectivity challenges associated with the use of these coupling partners. Both sym. and unsym. diynes can be applied in this protocol, affording single isomers not only in the synthesis of 1,3-enynes I but also in the one-step preparation of pyrroles and furans. This simple and highly atom economical strategy features wide functional group tolerance, good reproducibility and preparative scale utility. The manganese catalyst plays a crucial role in this C-H activation protocol, enabling high selectivity with previously challenging internal alkynes. Furthermore, the synthetic value of the method is highlighted by diverse post-functionalizations of the final products. The experimental process involved the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2HPLC of Formula: 14516-54-2)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.HPLC of Formula: 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium-catalyzed cross-coupling of lithium acetylides》 was published in Nature Catalysis in 2020. These research results belong to Helbert, Hugo; Visser, Paco; Hermens, Johannes G. H.; Buter, Jeffrey; Feringa, Ben L.. SDS of cas: 2635-13-4 The article mentions the following:

The incorporation of alkynes into organic mols. is one of the most valuable transformations for the formation of C-C bonds and provides a versatile handle for further modifications. The Sonogashira cross-coupling of acetylenes holds a prominent position among the suite of catalytic cross-coupling reactions that are key to modern synthesis. Herein, a method that is complementary to the Sonogashira reaction, demonstrating cross-coupling of lithium acetylides with aryl bromides is presented. The reactions take place under ambient conditions with short reaction times, affording the corresponding aryl acetylenes in good to excellent yields while displaying a remarkable functional group tolerance for an organolithium reaction, allowing the presence of a variety of organolithium-sensitive carbonyl functionalities. This developed cross-coupling methodol. offers ample opportunities to access a wide variety of acetylenes, as is illustrated by the facile preparation of key intermediates for chem. biol. and optoelectronic materials. After reading the article, we found that the author used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4SDS of cas: 2635-13-4)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.SDS of cas: 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Activating Effect of 3-Benzylidene Oxindoles on AMPK: From Computer Simulation to High-Content Screening》 was published in ChemMedChem in 2020. These research results belong to Novikova, Daria S.; Grigoreva, Tatyana A.; Ivanov, Gleb S.; Melino, Gerry; Barlev, Nickolai A.; Tribulovich, Vyacheslav G.. Recommanded Product: 1129-28-8 The article mentions the following:

AMP-activated protein kinase (AMPK) is currently the subject of intensive study and active discussions. AMPK performs its functions both at the cellular level, providing the switch between energy-consuming and energy-producing processes, and at the whole body level, particularly, regulating certain aspects of higher nervous activity and behavior. Control of such a ′main switch′ compensates dysfunctions and associated diseases. In the present paper, we studied the binding of 3-benzylidene oxindoles to the kinase domain of the AMPK α-subunit, which is thought to prevent its interaction with the autoinhibitory domain and thus result in the AMPK activation. For this purpose, we developed the cellular test system based on the AMPKAR plasmid, which implements the FRET effect, synthesized a number of 3-benzylidene oxindole compounds and simulated their binding to various sites of the kinase domain. The most probable binding site for the studied compounds was established by the correlation of calculated and exptl. data. The obtained results allow to analyze various classes of AMPK activators using virtual and high-content screening. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Recommanded Product: 1129-28-8 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Ligand Steric Effects of α-Diimine Nickel(II) and Palladium(II) Complexes in the Suzuki-Miyaura Cross-Coupling Reaction》 was published in ACS Omega in 2020. These research results belong to Talukder, Muktadir Md; Cue, John Michael O.; Miller, Justin T.; Gamage, Prabhath L.; Aslam, Amina; McCandless, Gregory T.; Biewer, Michael C.; Stefan, Mihaela C.. Product Details of 523-27-3 The article mentions the following:

A family of mono- and dinuclear Ni(II) and Pd(II) complexes I, II, III and IV with a diverse and versatile α-diimine ligand environment for Suzuki-Miyaura cross-coupling (SMC) reactions was examined To evaluate the ligand steric effects, including the bite angle in the reaction outcomes, the structural variation of the complexes I, II, III and IV was achieved by incorporating iminopyridine- and acenaphthene-based ligands. Moreover, the impact of substrate bulkiness was investigated by reacting various aryl bromides RBr (R = Ph, 1H-indol-5-yl, 4-bromo-2,3,5,6-tetrafluorophenyl, etc.) with phenylboronic acid, 2-naphthylboronic acid, and 9-phenanthracenylboronic acid. Yields were the best with the dinuclear complex, being nearly quant. (93-99%), followed by the mononuclear complexes I and IV, giving yields of 78-98%. Consequently, α-diimine-based ligands V and VI have the potential to deliver Ni-based systems I and II as sustainable catalysts in SMC. In the experiment, the researchers used 9,10-Dibromoanthracene(cas: 523-27-3Product Details of 523-27-3)

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.Product Details of 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Solar-driven tandem photoredox nickel-catalysed cross-coupling using modified carbon nitride》 was published in Chemical Science in 2020. These research results belong to Qin, Yangzhong; Martindale, Benjamin C. M.; Sun, Rui; Rieth, Adam J.; Nocera, Daniel G.. Reference of 1-Bromo-4-(trifluoromethyl)benzene The article mentions the following:

Nickel-catalyzed aryl amination and etherification were driven with sunlight using a surface-modified carbon nitride to extend the absorption of the photocatalyst into a wide range of the visible region. In contrast to traditional homogeneous photochem. methodologies, the lower cost and higher recyclability of the metal-free photocatalyst, along with the use of readily available sunlight, provide an efficient and sustainable approach to promote nickel-catalyzed cross-couplings. In the experimental materials used by the author, we found 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Reference of 1-Bromo-4-(trifluoromethyl)benzene)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Reference of 1-Bromo-4-(trifluoromethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy》 was published in Biomaterials Science in 2020. These research results belong to Hou, Rui; Liang, Xiaolong; Li, Xiaoda; Zhang, Xu; Ma, Xiaotu; Wang, Fan. Application of 17696-11-6 The article mentions the following:

Sonodynamic therapy (SDT) is a prospective therapy for many tumors by activation of sonosensitizers to produce reactive oxygen species (ROS) by ultrasound (US). However, limited generation of ROS and low drug delivery efficiency of sonosensitizers to the tumor tissue still hinder the application of SDT. Herein, an amphiphilic rose bengal (ARB) conjugate was designed to fabricate rose bengal microbubbles (RB-MBs) with high drug-loading contents (~6.8%) and excellent contrast enhancement capability for US imaging, well suited for detecting tumor location and size. More importantly, RB-MBs could be successfully converted into RB-NPs by local US exposure, resulting in ~7.5 times higher drug accumulation at the tumor tissue through the sonoporation effect as compared to RB-NPs and RB-MBs without US sonication. Meanwhile, using RB as the MB shell facilitated US energy transfer by the US mediated collapse of MBs through either a sonoluminescence or pyrolysis process; thus, the ROS generation efficiency could be greatly enhanced, resulting in a significantly higher tumor inhibition rate for the RB-MBs + US (~76.5%) in the HT-29 tumor model as compared to conventional MBs + US and RB-NPs + US (~23.8% and ~49.2%), resp. All these results suggested that this novel sonosensitizer delivery system of RB-MBs combined with US is a powerful strategy for remarkably enhancing SDT therapeutic efficacy with minimal side effects, showing great potential in cancer theranostics. In the experiment, the researchers used many compounds, for example, 8-Bromooctanoic acid(cas: 17696-11-6Application of 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Application of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Comparative Studies of the Corrosion Inhibition Efficacy of a Dicationic Monomer and Its Polymer against API X60 Steel Corrosion in Simulated Acidizing Fluid under Static and Hydrodynamic Conditions》 was published in ACS Omega in 2020. These research results belong to Odewunmi, Nurudeen A.; Solomon, Moses M.; Umoren, Saviour A.; Ali, Shaikh A.. Application of 629-03-8 The article mentions the following:

N1,N1-diallyl-N6,N6,N6-tripropylhexane-1,6-diaminium chloride (NDTHDC) and its polymer poly(N1,N1-diallyl-N6,N6,N6-tripropylhexane-1,6-diaminium chloride) (poly-NDTHDC) were synthesized and tested against API X60 carbon steel corrosion in 15 wt % HCl solution Weight loss, electrochem., and surface anal. techniques were used. Results show that poly-NDTHDC is better than NDTHDC. Moreover, 1000 mg/L NDTHDC protected the studied surface by 79.1% at 25 °C, while 100 mg/L poly-NDTHDC afforded 86.1% protection. Inhibition efficiency increases with temperature (up to 60 °C) but depreciates thereafter. NDTHDC and poly-NDTHDC perform better under the hydrodynamic condition than the static condition. TGA and FTIR results reveal that poly-NDTHDC is chem. and thermally stable. In the experiment, the researchers used 1,6-Dibromohexane(cas: 629-03-8Application of 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Application of 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Singlet oxygen stimulus for switchable functional organic cages》 was published in Chemical Science in 2020. These research results belong to Mongin, Cedric; Ardoy, Alejandro Mendez; Mereau, Raphael; Bassani, Dario M.; Bibal, Brigitte. Application In Synthesis of 9,10-Dibromoanthracene The article mentions the following:

Mol. cages 1a and 2a incorporating a 9,10-diphenylanthracene (DPA) chromophore were synthesized through a templated ring-closure metathesis approach that allows variation in cavity size through the introduction of up to three different pillars. Reversible Diels-Alder reaction between the DPA moiety and photogenerated singlet oxygen smoothly converted 1a and 2a to the corresponding endoperoxide cages 1b and 2b, which are converted back to 1a and 2a upon heating. Endoperoxide formation constitutes a reversible covalent signal that combines structural changes in the interior of the cage with introduction of two addnl. coordination sites. This results in a large modulation of the binding ability of the receptors attributed to a change in the location of the preferred binding site owing to the added coordination by the endoperoxide oxygen lone pairs. Cages 1a and 2a form complexes with sodium and cesium whose association constants are modified by 4-20 fold for Na+ and 200-450 fold for Cs+ upon conversion to 1b and 2b. DFT calculations show that in the anthracene form, cages 1a and 2a can bind 2 metal cations in their periphery so that each cation is coordinated by 4 oxygens and one amine nitrogen, whereas the endoperoxide cages 1b and 2b bind cations centrally in a geometry that favors coordination to the endoperoxide oxygens.9,10-Dibromoanthracene(cas: 523-27-3Application In Synthesis of 9,10-Dibromoanthracene) was used in this study.

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.Application In Synthesis of 9,10-Dibromoanthracene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Oxidative Addition of C-X Bonds and H-H Activation Using PNNP-Iron Complexes》 was published in ChemistrySelect in 2020. These research results belong to Gautam, Monika; Yatabe, Takafumi; Tanaka, Shinji; Satou, Naoto; Takeshita, Tomohiro; Yamaguchi, Kazuya; Nakajima, Yumiko. Safety of (Bromomethyl)cyclopropane The article mentions the following:

Iron(0) complex bearing a phenanthroline-based meridional PNNP ligand [{Fe(PNNP)}2(μ-N2)] (1) (PNNP = 2,9-bis((diphenylphosphino)methyl)-1,10-phenanthroline) smoothly reacted with CH3I at ambient temperature to cleave C-I bond, resulting in the formation of the corresponding oxidative addition product, [Fe(CH3)(I)(PNNP)] (2). Complex 2 was fully identified by NMR and its structure was determined by a single crystal x-ray diffraction study. Mechanistic study using cyclopropylmethyl bromide as a radical clock supported a radical pathway for the C-I bond cleavage of CH3I. Complex 2 underwent deprotonation on treatment with NaOtBu to form 4, which possessed a dearomatized phenanthroline backbone. Complex 4 further reacted with H2 to cleave H-H bond. The reaction was mediated by metal-ligand cooperation process that involves re-aromatization of the phenanthroline backbone of the PNNP ligand. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Safety of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Safety of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary